We are currently recruiting for the following studies:

  • The treatment of women with pudendal neuralgia or vulvodynia with topical amitriptyline & estriol/Mi-Gel 
  • For more information please contact us today, noting which study you are interested in.

  • All studies have been approved by the Human Research Ethics Committee (HREC)

Efficacy of a topical medication (Mi-Gel) in the treatment of women with painful intercourse

The study aim is to assess the effectiveness and safety of the application of a topical cream (amitriptyline + estriol) to reduce the impact of pain at the entry of the vagina with penetrative sex compared to a placebo cream. Each participant will trial either MiGel OR the placebo for 8 weeks without knowing which cream you are applying until after the completion of the study. You will be asked to fill in surveys online at the start and end of the 8 weeks, as well as after attempted or actual penetrative intercourse.

Please note this study has been revised to reduce clinic visits to one, in response to COVID-19. Randomised Double-Blinded, Placebo-Controlled, Cross-Over Trial Assessing the Efficacy of MiGel in the Treatment of Women with Entry Dyspareunia

For full details or contact Dr Karen Chan, Dr Chantelle Ruoss Principal Investigators, or Liz Howard, Clinical Researcher via support@whria.com.au

Main inclusion criteria

  • Women over 18 years old who have painful penetrative sex at the vaginal entry for greater than 3 months
  • Not used topical amitriptyline on the vulva for 6 weeks, no current use of oral amitriptyline 

Hyaluronic acid for the treatment of Perineal Pain/Pudendal Neuralgia

This study has finished recruitment and is collecting data until January 2021 to be analysed after that time.

The purpose of this study is to determine the effectiveness of pudendal nerve blocks with hyaluronic acid in the treatment of perineal pain. If you suffer from pain in the vagina, vulva, perineum, penis or scrotum, you may be eligible for this study.  

Congratulations to WHRIA’s Dr Lauren Kite, the recipient of the Robert Wrigley Pain Research Scholarship, 2018-2019. This grant will fund the study Randomised cross-over trial assessing the efficacy of adding hyaluronic acid to local anaesthetic in pudendal nerve blocks

For more information please contact us today.

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Privacy Policy for Research Participants

Any information about you that is obtained in connection with a research study will remain confidential and will be disclosed only with your permission. To ensure confidentiality, your information will be identified only by initials, date of birth and a study allocated number. The results of the study may be published or disclosed to other people in a way that will not identify you. The study will be conducted in accordance all relevant national and international regulatory guidelines to minimise negative impact on participants. Your medical records insofar as they relate to this study may be reviewed by officials of government related bodies or of any commercial company involved in this study. However, no personal details will be released. All data will be stored by the Women’s Health & Research Institute of Australia, under controlled (locked) access. Data will be retained for a minimum of ten years. Materials (including paper documents and computer discs) will be destroyed using an industrial shredding process.

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Last updated: 16 December 2020

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